HT-1 provides a programmable foundation for human cell manufacturing — built to support the distinct biological requirements of different cell types. By combining a 3D tissue-like microenvironment, in-vivo-like perfusion, integrated closed-system processing, and adaptive sensor-guided automation, HT-1 enables consistent, high-quality cell production.
The result is a new frontier in cell manufacturing: true human biology, scaled with clinical-grade reproducibility across runs and sites, from R&D through GMP.
Powering Immune Cell Therapies at Scale
High-Fidelity Growth for Stem and Progenitor Cells
A Platform Designed for Precision Engineering
3D Biology for
Stem-Derived
Cell Products
Structured Biology for Engineered Tissues
and Organoids
Powering
Immune Cell
Therapies at Scale
Why HT-1
Tissue-like activation
Supports functional phenotypes associated with persistence and reduces exhaustion.
High-density growth
Perfusion-stabilized culture enables rapid expansion from small starting populations.
Adaptive control
Sensor-guided programs adapt to biology, producing consistent outputs across donors.
Closed processing
Reduces operator variability and contamination risk for distributed workflows.
Immune cell therapies depend on reliable, functional phenotypes that persist in vivo, but conventional manufacturing exhausts cells and amplifies variability across donors and processes.
Ideal for
-
T cells (CAR-T, TCR-T) and TILs
-
Specialized immune programs (NK, Tregs)
-
Autologous and allogeneic workflows
High-Fidelity
Growth for Stem
and Progenitor Cells
Early-lineage cells rely on physical structure and localized biochemical cues during expansion to preserve stem-like states that determine functional capacity and graft performance.
Ideal for
-
Hematopoietic stem and progenitor cells (HSPC)
-
Mesenchymal stromal/stem cells (MSC)
-
Pluripotent stem cells (ESC and iPSC)
Why HT-1
Controlled microenvironment
Tissue-like growth matrix maintains stemness during expansion.
Programmable signaling
Stage-specific biochemical cues are delivered locally, reducing cytokine and reagent burden.
Improved expansion
Perfusion culture reduces stress and variability that can drive differentiation.
A Platform Designed for Precision Engineering
Genetic engineering is stressful to cells, and multi-instrument workflows amplify that stress. Added handling increases losses when cells are most fragile and payload reagents are most expensive.
Ideal for
-
CRISPR-modified and engineered cell programs
-
Viral and non-viral delivery approaches
-
Multi-step workflows requiring editing, recovery, and expansion
Why HT-1
Efficient payload delivery
3D cell membrane access improves consistency and efficiency for viral and non-viral delivery.
Adaptive control
Real-time sensing and perfusion maintain optimal conditions to improve viability and yield.
Integrated execution
Single-cartridge workflows reduce transfers and losses while preserving chain-of-custody.
3D Biology
for Stem-Derived
Cell Products
Stem-derived cells often require specific structural context and stage-specific biochemical cues over extended culture timelines to properly mature without drift or population heterogeneity.
Ideal for
-
Stem-derived cell replacement products including neurons and beta cells
-
Long-term differentiation and maturation workflows
-
Scale-up where 2D surface area becomes the bottleneck
Why HT-1
Tissue-like microenvironment
3D structure enables anchorage-dependent biology and promotes consistent functional differentiation.
Stage-specific programming
Programmable biochemical cues support multi-stage differentiation protocols.
Long-duration stability
Perfusion-stabilized culture sustains dense growth over extended timelines with higher reproducibility.
Volumetric scale-up
3D growth produces far more cells per footprint than multi-layer 2D vessels.
Structured Biology
for Engineered Tissues and Organoids
Many next-generation regenerative therapies and tissue models depend on spatial organization and cellular interactions to achieve architecture-dependent function.
Ideal for
-
Organoids and engineered tissue constructs
-
Co-cultures and architecture-dependent models
-
Regenerative grafts for neuronal, cardiovascular, and musculoskeletal repair
Why HT-1
Structured architecture
A 3D growth matrix supports spatial organization, co-culture, and tissue-like structure.
Perfused tissue constructs
Stable media transport sustains viability over time in tissue-scale systems.
Direct harvest
3D constructs can be harvested without dissociation to preserve tissue-like structures for downstream use.
Biology-First Microenvironment
Tissue-like contexts preserve phenotype, function, and potency across diverse cell types.
Sensor Guided
Automation
Real-time sensing and closed-loop control maintain optimal conditions for reproducible results.
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Perfusion-Driven
Stability
In-vivo-like nutrient delivery and waste removal supports long-duration, high-density cultures.
Closed, Standardized,
GMP-Ready
One platform, deployable anywhere, from R&D to clinical and commercial manufacturing